AbdomenGen: Sequential Volume-Conditioned Diffusion Framework for Abdominal Anatomy Generation
2026-04-14 • Computer Vision and Pattern Recognition
Computer Vision and Pattern Recognition
AI summaryⓘ
The authors introduce AbdomenGen, a new method that creates realistic 3D models of abdominal organs with controllable sizes. They use a special measurement called Volume Control Scalar (VCS) to adjust organ volumes independently and consistently. Their approach builds organ shapes one by one, keeping the whole anatomy coherent. Tests show their method accurately replicates organ shapes and can help simulate medical cases like enlarged livers for research.
computational phantomsdiffusion frameworkVolume Control Scalarabdominal organsorgan segmentationanatomical variationmedical imaginghepatomegalyWasserstein distancevolume modulation
Authors
Yubraj Bhandari, Lavsen Dahal, Paul Segars, Joseph Y. Lo
Abstract
Computational phantoms are widely used in medical imaging research, yet current systems to generate controlled, clinically meaningful anatomical variations remain limited. We present AbdomenGen, a sequential volume-conditioned diffusion framework for controllable abdominal anatomy generation. We introduce the \textbf{Volume Control Scalar (VCS)}, a standardized residual that decouples organ size from body habitus, enabling interpretable volume modulation. Organ masks are synthesized sequentially, conditioning on the body mask and previously generated structures to preserve global anatomical coherence while supporting independent, multi-organ control. Across 11 abdominal organs, the proposed framework achieves strong geometric fidelity (e.g., liver dice $0.83 \pm 0.05$), stable single-organ calibration over $[-3,+3]$ VCS, and disentangled multi-organ modulation. To showcase clinical utility with a hepatomegaly cohort selected from MERLIN, Wasserstein-based VCS selection reduces distributional distance of training data by 73.6\% . These results demonstrate calibrated, distribution-aware anatomical generation suitable for controllable abdominal phantom construction and simulation studies.